Neuroanesthesia & neurocritical care
Glial fibrillary acidic protein (GFAP) point-of-care measurement for prehospital diagnosis of intracranial hemorrhage in acute coma
Authors' conclusion
Increased GFAP plasma concentrations in patients with acute coma identify intracranial hemorrhage with high diagnostic accuracy.
Study context
- Population
- Patients admitted to the ED with prehospital diagnosis of acute coma (GCS 3–8), tertiary hospital, Germany
- Participants
- 143 patients
- Comparison
- Intracranial hemorrhage vs Other coma etiologies
- Intracranial hemorrhagen = 51
- Outcome
- Diagnostic accuracy of prehospital plasma GFAP (i-STAT Alinity point-of-care device) for intracranial hemorrhage
Methodological detailsprospective, single-centre, point-of-care
- Prospective
- Single-centre
- Point-of-care
Performance
As reported in the abstract
Plasma GFAP concentration and diagnostic accuracy for intracranial hemorrhage · prehospital
P < 0.001
- Sensitivity at optimal cut-off 101 pg/mL
- 94.1%
- Specificity
- 78.9%
- PPV
- 71.6%
- NPV
- 95.9%
Further findings
- In-hospital mortality risk associated with prehospital GFAP values
Original publication
GFAP point-of-care measurement for prehospital diagnosis of intracranial hemorrhage in acute coma. Crit Care. Published 5 April 2024. doi:10.
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