Perioperative medicine & outcomes
Goal-directed Perioperative Albumin Substitution Versus Standard of Care to Reduce Postoperative Complications: A Randomized Clinical Trial (SuperAdd Trial)
Primary resultResult — go to the resultRisk difference −2.7% 95% CI −8.3% to 2.9%Authors' conclusion
Maintaining serum albumin concentration of >30 g/L perioperatively cannot generally be recommended in high-risk noncardiac surgery patients.
Study context
- Population
- Adults, ASA 3 to 4 or undergoing high-risk surgery, whose serum albumin dropped <30 g/Lof 2509 included
- Participants
- 600 adults
- Comparison
- Goal-directed albumin substitution vs standard care
- Interventionn = 300
- Standard caren = 300reference
- Primary endpoint
- Postoperative complications Clavien-Dindo ≥2 in at least 1 of 9 domains
- Follow-up
- Until POD 15
Methodological detailssingle-centre, outcome assessor-blinded
- Single-centre
- Outcome assessor-blinded
Primary result
As reported in the abstract
Risk difference
−2.7%
95% CI −8.3% to 2.9%
Events by treatment group
Intervention vs Standard care
risk difference −2.7% (95% CI −8.3% to 2.9%)
Further findings
Albumin substituted
- Albumin substituted — Human albumin dose
- 60 g (40-80 g)
Original publication
Goal-directed Perioperative Albumin Substitution Versus Standard of Care to Reduce Postoperative Complications: A Randomized Clinical Trial (SuperAdd Trial). Ann Surg. Published 21 July 2023. doi:10.
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