Haemodynamic effects of methoxyflurane versus fentanyl and placebo in hypovolaemia: a randomised, double-blind crossover study in healthy volunteers
Authors' conclusion
The present study does not indicate that methoxyflurane has significant adverse haemodynamic effects in conscious adults experiencing hypovolaemia.
Study context
- Population
- Healthy volunteers exposed to experimental hypovolaemia (lower body negative pressure model)crossover
- Participants
- 15 volunteers
- Comparison
- Methoxyflurane vs Fentanyl vs Placebo
- Primary endpoint
- Effect of treatment on changes in CO during lower body negative pressure
Methodological detailsdouble-blinded, placebo-controlled, three-period crossover, healthy volunteers
- Double-blinded
- Placebo-controlled
- Three-period crossover
- Healthy volunteers
Primary result
As reported in the abstract
Changes in CO
- No statistically significant effect of treatment on changes in CO during lower body negative pressure
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Time to haemodynamic decompensationMethoxyflurane vs Fentanyl | 1.9 (0.4–3.4) | P = 0.010 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | HR (95% CI) | P value |
|---|---|---|
| Time to haemodynamic decompensationMethoxyflurane vs Placebo · no significant difference | −1.3 (−2.8 to 0.23) | P = 0.117 |
Changes in stroke volume and MAP
- No statistically significant effect of treatment on changes in stroke volume or MAP
Original publication
Haemodynamic effects of methoxyflurane versus fentanyl and placebo in hypovolaemia: a randomised, double-blind crossover study in healthy volunteers. BJA Open. Published 28 June 2023. doi:10.
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