Respiratory failure & ventilation
Health-related quality of life trajectories one year after COVID-19–induced ARDS: A secondary analysis of the CONFIDENT trial
Authors' conclusion
In this multicenter cohort of ARDS survivors, patients with shorter durations of mechanical ventilation, ICU and hospital stay experienced poorer HRQoL recovery, independently of baseline characteristics such as age or frailty.
Study context
- Population
- Survivors of mechanically ventilated COVID-19 ARDS who completed interviews at both day 90 and one year475 enrolled in trial
- Participants
- 156 survivors
- Primary endpoint
- Change in HRQoL (EQ-5D-5L utility score and EQ-VAS) between D90 and Y1 after ICU discharge
- Follow-up
- D90 to Y1
Methodological detailsplanned secondary analysis, multicentre, prospectively collected data
- Planned secondary analysis
- Multicentre
- Prospectively collected data
Primary result
As reported in the abstract
Change in HRQoL (EQ-score and EQ-VAS) between D90 and Y1
- EQ-score significantly improved between D90 and Y1
- p < 0.0001
- EQ-VAS significantly improved between D90 and Y1
- p = 0.0002
- Stagnation or deterioration in EQ-score over the year
- 38%
- Stagnation or deterioration in EQ-VAS over the year
- 43%
Further findings
Factors associated with health-related quality of life (HRQoL) recovery trajectory
- Longer duration of mechanical ventilation associated with greater EQ-score and EQ-VAS recovery
- P = 0.0002 and p = 0.025
- Longer intensive care unit (ICU) stay associated with greater EQ-score and EQ-VAS recovery
- P = 0.0002 and p = 0.0035
- Longer hospital stay associated with greater EQ-score and EQ-VAS recovery
- P = 0.0020 and p = 0.026
- Demographics and pre-admission frailty showed no impact on recovery trajectory
Original publication
Health-related quality of life trajectories one year after COVID-19–induced ARDS: A secondary analysis of the CONFIDENT trial. Ann Intensive Care. Published 16 January 2026. doi:10.
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