Pediatric anesthesia & critical care
Heart rate variability as a marker of multiple organ dysfunction syndrome in deeply sedated, prepubescent patients: a secondary analysis
Authors' conclusion
The results of our study in a PICU showed that HRV indices can differentiate between deeply sedated patients with MODS and those without.
Study context
- Population
- Deeply sedated, prepubescent patients in a PICUselected for analysis
- Participants
- 47 participants
- Comparison
- Medium/high multiple organ dysfunction syndrome (MODS) vs no/low MODS
- Primary endpoint
- Feasibility of HRV (10-minute window) to differentiate medium/high MODS from no/low MODS
Primary result
As reported in the abstract
HFnu
| Group | Value | AUC | Sensitivity | Specificity |
|---|---|---|---|---|
| Medium/high MODS | 0.35 | 0.75 | 0.78 | 0.74 |
| No/low MODS | 0.28 |
Value
Medium/high MODS0.35
No/low MODS0.28
AUC
Medium/high MODS0.75
No/low MODS— not stated in the abstract
Sensitivity
Medium/high MODS0.78
No/low MODS— not stated in the abstract
Specificity
Medium/high MODS0.74
No/low MODS— not stated in the abstract
- Medium/high MODS vs No/low MODS: P = 0.019 — HFnu higher in medium/high MODS
Further findings
| Outcome | Medium/high MODS | No/low MODS | P value |
|---|---|---|---|
| EnergySlightly but not significantly lower | 0.17 | 0.35 | P = 0.086 |
Energy (equivalent to SD of normal-to-normal intervals) vs pediatric Sequential Organ Failure Assessment (pSOFA) score
- Correlation with pSOFA score (r²)
- −0.31
- p = 0.03
Original publication
Heart rate variability as a marker of multiple organ dysfunction syndrome in deeply sedated, prepubescent patients: a secondary analysis. J Clin Monit Comput. Published 5 February 2026. doi:10.
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