Pediatric anesthesia & critical care
Evaluation of the Analgesia Nociception Index (ANI) as an indicator of discomfort in deeply sedated, prepubescent patients
Authors' conclusion
The ANI might be a good candidate for assessing discomfort in intubated, prepubescent patients in the PICU.
Study context
- Population
- Intubated, ventilated, sedated prepubescent children (girls 2–10 y, boys 2–12 y) in a pediatric intensive care unit (PICU)median age 7 [4
- Participants
- 50 participants
- Exposure
- ANI vs COMFORT Behavior Scale (CBS) across periods before, during and after care procedures
- Outcome
- Validity and performance of the ANI as an indicator of discomfort
Methodological detailsnon-interventional, single-centre, Single centre, June 1st, 2021 to November 31st, 2023
- Non-interventional
- Single-centre
- Single centre, June 1st, 2021 to November 31st, 2023
Main finding
As reported in the abstract
ANIi
P1
59
median · IQR 45–80
P2
33
median · IQR 26–42
P3
51
median · IQR 33–72
P2 vs P1: P < 0.0001 · P3 vs P2: P < 0.0001
- ANIi discriminated over-analgosedation (CBS score < 10) from normal analgosedation during P1 (AUROC)
- 0.694
Observational data: associations, not effects.
Further findings
Median
| Outcome | P2 | P3 | P value |
|---|---|---|---|
| CBS scoreP3 vs P2 · significant increase | 10 (IQR 7–13) | 12 (IQR 8–15) | P < 0.0001 |
Original publication
Evaluation of the Analgesia Nociception Index (ANI) as an indicator of discomfort in deeply sedated, prepubescent patients. J Clin Monit Comput. Published 9 September 2025. doi:10.
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