Hemodynamic and Postoperative Benefits of Remimazolam Over Sevoflurane: A Comparative Meta-Analysis
Authors' conclusion
Compared to sevoflurane, remimazolam appears to provide more stable intraoperative hemodynamics, a lower risk of hypotension requiring intervention, and faster recovery with fewer PONV episodes.
Study context
- Population
- Patients undergoing elective surgical procedures10 studies (6 RCTs, 4 retrospective)
- Participants
- 864 patients
- Comparison
- Remimazolam vs sevoflurane for maintenance of GA
- Remimazolamn = 433
- Sevofluranen = 431reference
- Outcome
- Intraoperative MAP, HR, extubation time, QoR-15, incidence of hypotension and PONV
Methodological detailsPRISMA guidelines
- PRISMA guidelines
Pooled result
As reported in the abstract
- Higher intraoperative mean arterial pressure (MAP) with remimazolam before intubation
- p = 0.05
- Higher intraoperative MAP with remimazolam after intubation
- p = 0.04
- Higher intraoperative MAP with remimazolam after incision
- p < 0.0001
- Intraoperative hypotension and rescue antihypotensive use significantly lower with remimazolam
- p < 0.00001
- Postoperative nausea and vomiting (PONV) significantly reduced with remimazolam
- p = 0.0005
Further pooled results
Rescue antiemetics
- Requirement significantly reduced with remimazolam
- P = 0.01
Postoperative pain scores
- No significant difference between groups
Original publication
Hemodynamic and Postoperative Benefits of Remimazolam Over Sevoflurane: A Comparative Meta-Analysis. J Cardiothorac Vasc Anesth. Published 4 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →