Perioperative medicine & outcomes
Hemodynamic Management Guided by the Hypotension Prediction Index in Abdominal Surgery: A Multicenter Randomized Clinical Trial
Primary resultResult — go to the resultRelative risk 0.89 95% CI 0.54–1.49Authors' conclusion
HPI-guided hemodynamic therapy did not reduce the incidence of postoperative AKI or overall complications compared to standard care.
Study context
- Population
- Patients 65 yr or older or older than 18 yr with ASA Physical Status greater than II undergoing moderate- to high-risk elective abdominal surgeryintention-to-treat analysis
- Participants
- 917 patients
- Comparison
- Hypotension Prediction Index (HPI)-guided hemodynamic management vs standard care
- HPIn = 459
- Standard caren = 458reference
- Primary endpoint
- Incidence of moderate-to-severe acute kidney injury (AKI)
- Follow-up
- First 7 days after surgery
Methodological detailsmulticentre, 28 hospitals, Conducted October 2022 to February 2024
- Multicentre
- 28 hospitals
- Conducted October 2022 to February 2024
Primary result
As reported in the abstract
Relative risk
0.89
95% CI 0.54–1.49
P = 0.66
Events by treatment group
HPI vs Standard care
RR 0.89 (95% CI 0.54–1.49); P = 0.66
Secondary outcomes
| Outcome | HPI | Standard care | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Overall complications | 31.9% | 29.7% | 1.08 (0.85–1.37) | P = 0.52 | |
| 30-day mortality | 1.1% | 0.9% | 1.35 (0.36–5.10) | P = 0.66 | |
| 0.20.5125Relative risk (log scale) |
Length of hospital stay · in both groups
Need for RRT
- Did not differ between groups
Original publication
Hemodynamic Management Guided by the Hypotension Prediction Index in Abdominal Surgery: A Multicenter Randomized Clinical Trial. Anesthesiology. Published 2 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →