Hemodynamic profile of cirrhotic patients with sepsis and septic shock: A propensity score matched case-control study
Authors' conclusion
Septic patients with cirrhosis had higher LVEF with lower Ea and SVR with higher Ees and significantly lower Ea/Ees suggesting vasodilation as the principal driver of the hyperdynamic profile in cirrhosis.
Study context
- Population
- Septic patients with echocardiogram within 3 days of ICU admission828 matched
- Participants
- 3,151 patients
- Comparison
- Septic patients with vs without cirrhosis
- Cirrhosisn = 422
- Outcome
- Echocardiographic hemodynamic profile (LV systolic function, arterial load)
- Follow-up
- Within 3 days of ICU admission
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Echocardiographic parameters, matched cohort
- LV ejection fraction, Cirrhosis vs No cirrhosis (%), p < 0.001
- 64 vs.56%
- Stroke volume, Cirrhosis vs No cirrhosis (ml), p < 0.001
- 72 vs.48 ml
- Arterial elastance (Ea), Cirrhosis vs No cirrhosis, p < 0.001
- 1.35 1vs.20.3
- Systemic vascular resistance, Cirrhosis vs No cirrhosis (dynes/s/m-5), p = 0.001
- 851 vs.1209 dynes/s/m-5
- LV elastance (Ees), Cirrhosis vs No cirrhosis, p = 0.002
- 2.83 vs 2.45
- Ventricular-arterial coupling (Ea/Ees), Cirrhosis vs No cirrhosis, p < 0.001
- 0.48 vs. 0.86
Observational data: associations, not effects.
Original publication
Hemodynamic profile of cirrhotic patients with sepsis and septic shock: A propensity score matched case-control study. J Crit Care. Published 8 February 2024. doi:10.
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