Pediatric anesthesia & critical care
Heparin Versus Bivalirudin in Pediatric Patients Assisted With Mechanical Circulatory Support: A Retrospective Before-and-after Study
Authors' conclusion
In a cohort of children with heart failure, bivalirudin use was associated with a reduction in thrombotic events in Berlin Heart patients compared with heparin over a period of 30 days.
Study context
- Population
- Pediatric patients on mechanical circulatory support for cardiac failure, tertiary pediatric cardiac ICU
- Participants
- 36 patients
- Exposure
- Bivalirudin vs Heparin
- Bivalirudinn = 18
- Heparinn = 18reference
- Outcome
- Incidence of thrombotic events
- Follow-up
- First 30 days of ICU admission
Methodological detailsbefore-and-after, single-centre
- Before-and-after
- Single-centre
Main finding
As reported in the abstract
Thrombotic events, Berlin Heart patients (subgroup)
P = 0.005
Observational data: associations, not effects.
Further findings
Death, ECMO patients (subgroup)
P = 0.169
| Outcome | Bivalirudinevents | Heparin | P value |
|---|---|---|---|
| Thrombosis, ECMO patients (subgroup) | 0 | 8.3% | P = 0.40 |
| Cerebrovascular events, Berlin Heart patients (subgroup) | 0 | 30% | |
| Death, Berlin Heart patients (subgroup) | 0 | 30% | P = 0.054 |
| Cerebrovascular events, ECMO patients (subgroup) | 0 | 0 events | |
| Out-of-range partial thromboplastin time valuesBoth Berlin Heart and ECMO patients | P < 0.0001 |
Out-of-range partial thromboplastin time values
- Higher in the heparin group in both Berlin Heart and ECMO patients
Original publication
Heparin Versus Bivalirudin in Pediatric Patients Assisted With Mechanical Circulatory Support: A Retrospective Before-and-after Study. J Cardiothorac Vasc Anesth. Published 12 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →