Pediatric anesthesia & critical care
An Insight Into a Potential Antithrombin-Independent Mechanism of Inadequate Heparin Response in Neonates and Infants Undergoing Pediatric Cardiac Surgery: An Exploratory Study
Authors' conclusion
Lower α2-macroglobulin and protein S levels may be at least partly responsible for inadequate heparin response in the study cohort.
Study context
- Population
- Neonates and infants undergoing cardiac surgery with CPB, tertiary academic hospital, US, May 2022–February 2023
- Participants
- 30 neonates
- Exposure
- Inadequate heparin response vs heparin response
- Outcome
- Coagulation factor profile
Methodological detailssingle-centre, exploratory
- Single-centre
- Exploratory
Main finding
As reported in the abstract
- Antithrombin levels comparable between groups
- α2-macroglobulin significantly lower in the inadequate heparin response group
- Protein S significantly lower in the inadequate heparin response group
Observational data: associations, not effects.
Original publication
An Insight Into a Potential Antithrombin-Independent Mechanism of Inadequate Heparin Response in Neonates and Infants Undergoing Pediatric Cardiac Surgery: An Exploratory Study. J Cardiothorac Vasc Anesth. Published 26 May 2026. doi:10.
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