High Fresh Frozen Plasma to Red Blood Cell Ratio and Survival Outcomes in Blunt Trauma
Main findingResult — go to the resultOdds ratio 0.73 95% CI 0.56–0.93Authors' conclusion
In this cohort study, a high FFP to RBC ratio was associated with favorable survival in patients with severe blunt trauma.
Study context
- Population
- Adults with severe blunt trauma without severe head injury (Injury Severity Score ≥16 and head Abbreviated Injury Scale <3), Japan Trauma Data Bank, 2019–2022analysed
- Participants
- 1,954 adults
- Exposure
- High fresh frozen plasma (FFP):RBC ratio vs low FFP:RBC ratio
- High-FFPn = 976
- Outcome
- All-cause in-hospital mortality
Methodological detailsmulticentre, registry (Japan Trauma Data Bank), inverse probability treatment weighting
- Multicentre
- Registry (Japan Trauma Data Bank)
- Inverse probability treatment weighting
Main finding
As reported in the abstract
Odds ratio
0.73
95% CI 0.56–0.93
High-FFP vs Low-FFP
OR 0.73 (95% CI 0.56–0.93)
Observational data: associations, not effects.
Further findings
Nonlinear relationship between FFP:RBC ratio and outcomes
- Nonlinear trends noted, suggesting a potential ceiling effect on transfusion benefits
Original publication
High Fresh Frozen Plasma to Red Blood Cell Ratio and Survival Outcomes in Blunt Trauma. JAMA Surg. Published 1 November 2024. doi:10.
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