Perioperative medicine & outcomes
High-Sensitivity Cardiac Troponin T and Frailty Predict Short-Term Mortality in Patients ≥75 Years Undergoing Emergency Abdominal Surgery: A Prospective Observational Study
Authors' conclusion
After emergency abdominal surgery in elderly patients, increased preoperative troponin concentration and frailty were independent predictors of 30-day mortality.
Study context
- Population
- Patients ≥75 years undergoing emergency abdominal surgery (surgery within 72 hours), university hospital in Norway; vascular procedures and palliative surgery for inoperable malignancies excluded156 eligible
- Participants
- 146 patients
- Exposure
- Preoperative high-sensitivity cardiac troponin T (hs-cTnT) and frailty as predictors of mortality
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio (95% CI)
hs-cTnT ≥34 ng/Lindependent predictor
3.14(1.13–9.45)
Frailty (CFS)per CFS point; independent predictor
1.42(1.01–2.00)
Per CFS point, as printed
- 30-day mortality rate
- 12% (18 of 146)
- AUC, troponin + frailty
- 0.79 (95% CI 0.68-0.88)
- AUC, troponin alone
- 0.69 (95% CI 0.55-0.83)
- AUC, frailty alone
- 0.69 (95% CI 0.57-0.82)
Observational data: associations, not effects.
Secondary outcomes
Composite of 30-day mortality and MACE
| HR (95% CI) | ||
|---|---|---|
| hs-cTnT ≥34 ng/L | 2.58 (1.07–6.49) | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| Composite of 30-day mortality and MACE · 30 daysFrailty (CFS) · per CFS point | 1.37 (1.02–1.84) | |
| 0.512Hazard ratio (log scale) |
Troponin above 99th percentile upper reference limit (URL) and frailty prevalence
- Troponin >99th percentile URL preoperatively
- 83%
- Troponin >99th percentile URL postoperatively
- 89%
- Vulnerable or frail (Clinical Frailty Scale (CFS) ≥4)
- 53%
Original publication
High-Sensitivity Cardiac Troponin T and Frailty Predict Short-Term Mortality in Patients ≥75 Years Undergoing Emergency Abdominal Surgery: A Prospective Observational Study. Anesth Analg. Published 15 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →