Perioperative medicine & outcomes
The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data
Authors' conclusion
Being frail is associated with a significantly increased risk for ICU mortality in older patients, while being vulnerable alone did not significantly differ.
Study context
- Population
- Acutely admitted intensive care unit (ICU) patients (elective admissions excluded); older patients ≥ 65 years
- Participants
- 23,989 participants · 12 studies
- Comparison
- Frail vs non-frail
- Outcome
- ICU mortality
Methodological detailssystematic search, multiple imputation, Cox models adjusted for age, sex and illness acuity score
- Systematic search
- Multiple imputation
- Cox models adjusted for age, sex and illness acuity score
Pooled result
As reported in the abstract
Older patients (≥ 65 years), complete case analysis: independent association with ICU mortality
HR 1.34 (95% CI 1.25-1.44), p < 0.0001
Older patients (≥ 65 years), multiple imputation analysis, adjusted for SOFA: independent association with ICU mortality
HR 1.35 (95% CI 1.26-1.45), p < 0.0001
Further pooled results
Vulnerable vs frail, older patients
- Being vulnerable (Clinical Frailty Scale (CFS) 4) alone did not significantly differ from being frail
CFS categories vs CFS 1-3 (adjusted)
- CFS 4-5, 6 and ≥ 7 associated with significantly worse outcome vs CFS 1-3
Original publication
The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data. Ann Intensive Care. Published 3 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →