Perioperative medicine & outcomes
Effect of exercise prehabilitation on quality of recovery after cardiac surgery: a single-centre randomised controlled trial
Authors' conclusion
A 5-week programme of physical prehabilitation in predominately prefrail patients was safe, but it did not enhance quality of recovery scores after surgery.
Study context
- Population
- Vulnerable and frail patients (Clinical Frailty Scale 4–6) undergoing cardiac surgery138 in primary analysis
- Participants
- 164 participants
- Comparison
- Physical prehabilitation vs standard care
- Primary endpoint
- QoR-15 score
- Follow-up
- Third day after surgery
Methodological detailssingle-blinded, parallel-arm, superiority, single-centre, Compliance with 5-week prehabilitation programme 82%
- Single-blinded
- Parallel-arm
- Superiority
- Single-centre
- Compliance with 5-week prehabilitation programme 82%
Primary result
As reported in the abstract
No between-group difference in QoR-15 scores
median difference −3 −3
95% CI −9 to 3
Secondary outcomes
Early and late major adverse cardiac and cerebrovascular events (MACCE)
- No between-group differences in early and late MACCE
DAH30
- No between-group difference in DAH30 (P=0.779)
Disability (World Health Organization Disability Assessment Schedule (WHODAS) 2.0) · 90 days after surgery
- Lower disability levels in prehabilitated vs control patients
- P = 0.022; mean difference −9% −9% (95% CI −17% to −2%)
Safety
- Adverse exercise-induced events — Prehabilitation
- 0 events
Original publication
Effect of exercise prehabilitation on quality of recovery after cardiac surgery: a single-centre randomised controlled trial. Br J Anaesth. Published 7 November 2024. doi:10.
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