High‐volume patient‐controlled epidural vs. programmed intermittent epidural bolus for labour analgesia: a randomised controlled study
Authors' conclusion
In conclusion, patient-controlled epidural analgesia is non-inferior to programmed intermittent epidural bolus if equal volumes of patient-controlled epidural analgesia are used to maintain labour analgesia and superior with respect to local anaesthetic consumption.
Study context
- Population
- Nulliparous women receiving epidural labour analgesia
- Participants
- 360 women
- Comparison
- Patient controlled vs Programmed intermittent
- Primary endpoint
- Incidence of breakthrough pain and total analgesic intake (positive if PCEA non-inferior for breakthrough pain and superior for local anaesthetic consumption)
Methodological detailsmulticentre, non-inferiority
- Multicentre
- Non-inferiority
Primary result
As reported in the abstract
Breakthrough pain; total ropivacaine consumption
P for non-inferiority = 0.003
- Total ropivacaine consumption lower in the PCEA-group (mean difference)
- 15.3 mg
Secondary outcomes
Motor block, patient satisfaction scores
- Similar across both groups
Safety
Maternal and neonatal outcomes
- Similar across both groups
Original publication
High‐volume patient‐controlled epidural vs. programmed intermittent epidural bolus for labour analgesia: a randomised controlled study. Anaesthesia. Published 20 June 2023. doi:10.
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