Neuroanesthesia & neurocritical care
Higher intracranial pressure variability is associated with lower cerebrovascular resistance in aneurysmal subarachnoid hemorrhage
Authors' conclusion
This study corroborates the hypothesis that higher ICPV, at least in the 4-h interval, is favorable and may reflect more compliant and possibly more active cerebral vessels.
Study context
- Population
- Aneurysmal subarachnoid hemorrhage (aSAH) patients treated in the Neurointensive Care Unit, Uppsala, Sweden, 2012–2020, with ICP monitoring and ≥1 xenon-enhanced computed tomography (Xe-CT) scan for cortical cerebral blood flow (CBF) within the first 2 weeks post-ictus
- Participants
- 147 patients
- Outcome
- Association of intracranial pressure variability (ICPV) (subminute, 30-min, 4 h intervals) with cerebrovascular resistance (CVR = CPP at Xe-CT / concurrent CBF) and CBF
- Follow-up
- Early phase (days 1-3) and vasospasm phase (days 4-14)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Association of ICPV with CVR and CBF · Vasospasm phase (days 4-14)
Higher ICPV-4h independently associated with lower cerebrovascular resistance (CVR) (multiple linear regression), β
- 0.19
p < 0.05
Higher ICPV-4h associated with higher global cortical CBF (univariate analysis), r
0.19
p < 0.05
Observational data: associations, not effects.
Original publication
Higher intracranial pressure variability is associated with lower cerebrovascular resistance in aneurysmal subarachnoid hemorrhage. J Clin Monit Comput. Published 17 July 2022. doi:10.
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