Neuroanesthesia & neurocritical care
The Optimal pressure reactivity index range is disease-specific: A comparison between aneurysmal subarachnoid hemorrhage and traumatic brain injury
Authors' conclusion
Extreme PRx values in both directions were unfavorable in aSAH, possibly as high PRx could indicate proximal vasospasm with exhausted distal vasodilatory reserve, while very negative PRx could reflect myogenic hyperreactivity with suppressed cerebral blood flow. Only elevated PRx was unfavorable in TBI, possibly as pressure passive vessels may be a more predominant pathomechanism in this disease.
Study context
- Population
- Aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) patients treated in the neurointensive care, Uppsala, Sweden, 2008–2018
- Participants
- 487 vs 413
- Exposure
- aSAH vs TBI
- aSAHn = 487
- TBIn = 413
- Outcome
- Favorable outcome (GOS-E 5 to 8) in relation to %GMT of PRx intervals
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Favorable outcome (GOS-E 5 to 8) by %GMT of PRx interval (multiple logistic regression)
- aSAH: higher %GMT of PRx in −1.0 to −0.5 and + 0.75 to + 1.0 independently associated with lower rate of favorable outcome
- TBI: only PRx in + 0.75 to + 1.0 independently associated with lower rate of favorable outcome
Observational data: associations, not effects.
Original publication
The Optimal pressure reactivity index range is disease-specific: A comparison between aneurysmal subarachnoid hemorrhage and traumatic brain injury. J Clin Monit Comput. Published 4 May 2024. doi:10.
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