Neuroanaesthesia & neurocritical care
Temporal dynamics of intracranial pressure (ICP), PRx, cerebral perfusion pressure (CPP), and CPPopt in relation to functional outcome in spontaneous cerebellar hemorrhage
Authors' conclusion
Cerebral physiological monitoring provides important prognostic information in sCH. Optimal targets differ from supratentorial acute brain injuries, with an apparent benefit of higher CPP in sCH.
Study context
- Population
- Adults with spontaneous cerebellar hemorrhage (sCH) treated at the neurointensive care unit, Uppsala University Hospital, Sweden, 2008–2024, with high resolution monitoring data
- Participants
- 94 adults
- Exposure
- %GMT of ICP, PRx, CPP and ΔCPPopt within/outside thresholds in relation to GODS
- Outcome
- Glasgow Outcome Scale at discharge (GODS)
- Follow-up
- Discharge
Methodological detailssingle-centre, exploratory
- Single-centre
- Exploratory
Main finding
As reported in the abstract
Association of cerebral physiological variables with GODS
- ICP > 15 mmHg: descriptive trend toward unfavorable outcome irrespective of duration, particularly first two days post-injury; not significant
- p = 0.85
- Sustained PRx > 0.2: descriptive trend toward worse outcome, expanding vulnerability over time; not significant
- p = 0.26
- CPP < 60 mmHg associated with worse outcome; CPP > 80 mmHg associated with favorable outcome
- p = 0.02, respectively
- ΔCPPopt < −5 mmHg associated with worse outcome
- p = 0.04
Observational data: associations, not effects.
Original publication
Temporal dynamics of ICP, PRx, CPP, and CPPopt in relation to functional outcome in spontaneous cerebellar hemorrhage. Crit Care. Published 10 June 2026. doi:10.
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