Neuroanesthesia & neurocritical care
Autoregulation-guided intracranial pressure and cerebral perfusion pressure targets in different subtypes and characteristics of traumatic brain injury
Authors' conclusion
This study provides novel insights into cerebral physiology across various TBI subtypes by delineating safe and hazardous thresholds for ICP, PRx, and CPP. The acceptable lower limit of CPP appears to be directly proportional to the PRx.
Study context
- Population
- Patients with acute traumatic brain injury (TBI) with intracranial pressure (ICP) and arterial BP monitoring and 6-month Glasgow Outcome Scale-Extended (GOSE) outcome
- Participants
- 187 patients
- Exposure
- Associations of PRx with ICP or cerebral perfusion pressure (CPP), and their combined relation to 6-month functional outcome
- Outcome
- Functional outcome (Glasgow Outcome Scale-Extended)
- Follow-up
- 6 months
Main finding
As reported in the abstract
Composite variable 2 the only variable independently associated with favorable outcome in the multivariable model: OR
1.026
95% CI 1.006–1.046P = 0.012
Observational data: associations, not effects.
Further findings
Tolerance to lower CPP by subgroup (decompressive craniectomy (DC), injury type, age)
- Patients without DC, with diffuse injury or younger age tolerated lower CPP better when autoregulation was preserved than patients with DC, focal injury or older age
Original publication
Autoregulation-guided intracranial pressure and cerebral perfusion pressure targets in different subtypes and characteristics of traumatic brain injury. Crit Care. Published 20 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →