Neuroanaesthesia & neurocritical care
Stable tissue oxygen cerebral perfusion pressure (stoCPP): Proof of concept for a novel method for the assessment of optimum cerebral perfusion pressure in severe traumatic brain injury
Authors' conclusion
stoCPP was defined in all patients from raw unfiltered data using Bayesian-optimised parameters and per-subject calibrated r² thresholds, and demonstrated close correspondence with CPPopt.
Study context
- Population
- Patients with severe TBI enrolled in the BONANZA-GT trial with continuous MAP, intracranial pressure (ICP), cerebral perfusion pressure (CPP) and PbtO₂ monitoring
- Participants
- 9 patients
- Exposure
- stoCPP range vs CPPopt
- Outcome
- stoCPP generation and agreement with CPPopt
Methodological detailsproof-of-concept study, Bayesian-optimised algorithm parameters, per-subject block-shuffle calibrated r² thresholds
- Proof-of-concept study
- Bayesian-optimised algorithm parameters
- Per-subject block-shuffle calibrated r² thresholds
Main finding
As reported in the abstract
- stoCPP generated from raw unfiltered data (patients)
- 9
- Analysis windows with lower limit of stoCPP range (LLstoCPP) defined
- ≈22%
- CPPopt point estimates within stoCPP range (observations)
- 76.2%
- Mean stoCPP width
- 22.8 mmHg
- Bland-Altman lower bounds, mean bias (n = 102 independent estimates)
- 4.1 mmHg (SD 7.3 mmHg)
- Bland-Altman 95% limits of agreement
- - 10.1 to + 18.4 mmHg
- Trough depth degraded with temporal misalignment of PbtO₂ signal, Kendall's W
- 0.557, p < 0.001
Observational data: associations, not effects.
Original publication
Stable tissue oxygen cerebral perfusion pressure (stoCPP): Proof of concept for a novel method for the assessment of optimum cerebral perfusion pressure in severe traumatic brain injury. J Clin Monit Comput. Published 29 August 2026. doi:10.
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