Neuroanesthesia & neurocritical care
A noninvasive method for assessing optimal cerebral perfusion pressure
Main finding · Agreement of MAPopt derived from noninvasive P2/P1 ratio vs invasive PRxResult — go to the resultr 0.905Authors' conclusion
The noninvasive P2/P1 ratio, serving as a marker of intracranial compliance, may effectively and accurately infer the optimal systemic mean arterial pressure.
Study context
- Population
- ICU patients with severe acute brain injury requiring invasive intracranial pressure (ICP) monitoring (68% severe TBI, 15% spontaneous SAH)
- Participants
- 114 patients
- Exposure
- Noninvasive P2/P1 ratio vs invasive PRx for determining MAPopt
- Outcome
- Agreement between MAPopt derived from invasive PRx and from noninvasive P2/P1 ratio
Methodological detailsmethod comparison
- Method comparison
Main finding
As reported in the abstract
Agreement of MAPopt derived from noninvasive P2/P1 ratio vs invasive PRx
r
0.905
P < 0.0001
- Bland-Altman mean difference between the two methods (good agreement)
- +2.00 mmHg
- Bland-Altman 95% limits of agreement
- −9.87 mmHg to +13.86 mmHg
Observational data: associations, not effects.
Original publication
A noninvasive method for assessing optimal cerebral perfusion pressure. Crit Care. Published 11 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →