Neuroanesthesia & neurocritical care
Predicting short-term outcomes in brain-injured patients: a comprehensive approach with transcranial Doppler and intracranial compliance assessment
Authors' conclusion
The combined noninvasive neuromonitoring approach using eCPP and P2/P1 ratio demonstrated improved performance in predicting outcomes during the early phase after acute brain injury.
Study context
- Population
- Neurocritical patients with intracranial pressure (ICP) monitoring, assessed within the first 5 days of hospital admission (severe TBI, SAH, ischemic or hemorrhagic stroke)
- Participants
- 98 patients
- Exposure
- Noninvasive neuromonitoring (Transcranial Doppler (TCD): eICP, eCPP; B4C: P2/P1 ratio), alone and combined, for prediction of short-term outcomes
- Outcome
- Short-term outcomes: Therapy intensity levels (TIL) 0 (STO 1), TIL 1-3 (STO 2) and death (STO 3)
- Follow-up
- Seventh day after last data collection
Main finding
As reported in the abstract
Prediction of short-term outcomes
- ICP predicting early mortality
- p = 0.02
- P2/P1 predicting early mortality
- p = 0.02
- eCPP predicting early mortality
- p = 0.006
- P2/P1 only parameter significant for prediction of short-term outcomes (STO) 1
- p = 0.03
- AUC to predict death (STO 3), P2/P1 + eCPP (highest combined)
- 0.85
Observational data: associations, not effects.
Further findings
Identification of ICP > 20 mmHg
- AUC, P2/P1 + eICP
- 0.72
Original publication
Predicting short-term outcomes in brain-injured patients: a comprehensive approach with transcranial Doppler and intracranial compliance assessment. J Clin Monit Comput. Published 6 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →