In-Hospital Mortality and Associated Risk Factors in Cardiac Surgery–Related Perioperative Acute Kidney Injury Patients Treated with Continuous Renal Replacement Therapy: A Retrospective Cohort Study
Authors' conclusion
The SOFA score at CRRT initiation serves as an independent predictor of in-hospital mortality in CS-AKI patients requiring CRRT, outperforming both the APACHE II score and the EuroSCORE II score. IABP use and a mechanical ventilation time >96 hours also were independent predictors of in-hospital mortality.
Study context
- Population
- Adults with cardiac surgery-related perioperative AKI requiring continuous renal replacement therapy (CRRT), cardiac surgery intensive care unit (ICU), 2013–2022
- Outcome
- In-hospital mortality and independent predictors (multivariable Cox regression)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
In-hospital mortality rate
50.5%
SOFA score, per 1-point increase: HR
1.46
95% CI 1.36–1.56
Intra-aortic balloon pump (IABP) use: HR
2.11
95% CI 1.30–3.42
Mechanical ventilation time >96 hours: HR
3.06
95% CI 1.82–5.15
Observational data: associations, not effects.
Further findings
| Outcome | SOFA | APACHE II | EuroSCORE II |
|---|---|---|---|
| Predictive accuracy for in-hospital mortality (ROC analysis) | |||
| AUC | 0.93 | 0.72 | 0.61 |
Predictive accuracy for in-hospital mortality (ROC analysis)
- SOFA significantly greater predictive accuracy than APACHE II and EuroSCORE II
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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