Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes
Authors' conclusion
The hyperinflammatory and hypoinflammatory phenotypes have distinct transcriptional and metagenomic features that could be leveraged for precision treatment strategies.
Study context
- Population
- Patients with sepsis enrolled in a two-hospital prospective cohort study
- Participants
- 76 vs 113
- Comparison
- Hyperinflammatory vs hypoinflammatory sepsis phenotype
- Hyperinflammatoryn = 76
- Hypoinflammatoryn = 113reference
Methodological detailshost and microbe blood metagenomics, two-hospital, latent class analysis-derived phenotypes
- Host and microbe blood metagenomics
- Two-hospital
- Latent class analysis-derived phenotypes
Primary result
As reported in the abstract
Host gene expression and plasma metagenomics by phenotype
Genes differentially expressed between phenotypes
5,755 genes
31%
Further findings
Concordance with other phenotypes
- Significant overlap with ARDS transcriptional subtypes (reactive and uninflamed) and sepsis subtypes (SRS1-2)
Corticosteroid effect by phenotype (VANISH trial data)
- Corticosteroids might have a detrimental effect in hypoinflammatory phenotype
Original publication
Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. Am J Respir Crit Care Med. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →