Host–Microbe Multiomic Profiling Predicts Mortality in Sepsis
Authors' conclusion
Taken together, our findings provide a conceptual advance in the understanding of host and microbial factors associated with mortality in critical illness and demonstrate a new approach to mortality prediction in sepsis.
Study context
- Population
- Critically ill adults with adjudicated sepsis status; whole blood and plasma within 24 h of admission
- Participants
- 321 adults
- Comparison
- Host-microbe metagenomic and host transcriptomic classifiers vs APACHE III score for sepsis mortality prediction
- Outcome
- Prediction of sepsis mortality
Methodological detailsmultiomic (transcriptomic, proteomic, metagenomic), support vector machine-based classifiers
- Multiomic (transcriptomic, proteomic, metagenomic)
- Support vector machine-based classifiers
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| Host-microbe metagenomic classifier | 0.79 |
| Host transcriptomic classifier | 0.75 |
| APACHE III | 0.69 |
AUC
Host-microbe metagenomic classifier0.79
Host transcriptomic classifier0.75
APACHE III0.69
- Host-microbe metagenomic classifier vs APACHE III: P < 0.05 — paired DeLong test; performed better
- Host transcriptomic classifier vs APACHE III: P < 0.05 — paired DeLong test; performed better
Further findings
Host factors associated with mortality in sepsis
- Mortality associated with increased expression of neutrophil degranulation genes, lower expression of T-cell signaling genes, and higher IL-8 levels
Microbial factors associated with mortality in sepsis
- Mortality associated with greater microbial mass and greater bacterial relative dominance
Broader group incl. culture-negative or indeterminate sepsis (subgroup)
- Similar findings observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Host–Microbe Multiomic Profiling Predicts Mortality in Sepsis. Am J Respir Crit Care Med. Published 11 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →