Host Response Stratification in Malarial and Non-malarial Sepsis: A Prospective, Multicenter Analysis From Uganda
Authors' conclusion
Host responses are largely conserved in malarial and non-malarial sepsis but may be distinguished by a signature of relative immunosuppression in the former.
Study context
- Population
- Adults (age ≥ 18 yr) hospitalized with sepsis at public hospitals in Ugandadiscovery n = 238
- Exposure
- Malarial vs non-malarial sepsis
- Outcome
- Host response (protein expression) in malarial vs non-malarial sepsis
Methodological detailsproteomic analysis, multicentre, discovery and validation cohorts, Olink proteomics
- Proteomic analysis
- Multicentre
- Discovery and validation cohorts
- Olink proteomics
Main finding
As reported in the abstract
- Frequency of malarial sepsis, discovery cohort
- 20%
- Frequency of malarial sepsis, validation cohort
- 28%
- Proteins differentially expressed between malarial and non-malarial sepsis, both cohorts (Benjamini-Hochberg-adjusted p ≤ 0.05)
- ≤ 8%
- Classifier AUC for malarial sepsis, discovery cohort
- 0.73 (95% CI 0.65-0.81)
- Classifier AUC for malarial sepsis, validation cohort (0.65-0.79)
- 0.72
- Brier score, discovery cohort
- 0.14
- Brier score, validation cohort
- 0.18
Observational data: associations, not effects.
Original publication
Host Response Stratification in Malarial and Non-malarial Sepsis: A Prospective, Multicenter Analysis From Uganda. Crit Care Med. Published 12 February 2025. doi:10.
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