How severity and classification of pulmonary hypertension affect pregnancy outcomes: a systematic review and timeline
Authors' conclusion
This systematic review provides new insights for preconception counseling on pregnancy risks related to PH and suggests that PH classification and severity should be carefully considered in determining an individual's pregnancy-associated risk.
Study context
- Population
- Pregnant women with pulmonary hypertension (PH)66 publications
- Comparison
- Pregnancy outcomes by PH severity and classification, and by publication period
- Outcome
- Maternal survival (mortality) during pregnancy and the peripartum period
Methodological detailstimeline, 9097 potential studies from 1967 to 2021 screened, Severity defined by echocardiographic-estimated pulmonary artery pressures in published studies
- Timeline
- 9097 potential studies from 1967 to 2021 screened
- Severity defined by echocardiographic-estimated pulmonary artery pressures in published studies
Pooled result
As reported in the abstract
Maternal mortality by publication period
Further pooled results
Maternal mortality by PH severity and classification (subgroup)
- Mild disease
- 0.8%
- Eisenmenger syndrome
- 26.2%
- Idiopathic pulmonary arterial hypertension
- 7.4-24.0%
- Mortality lower in mild disease
Original publication
How severity and classification of pulmonary hypertension affect pregnancy outcomes: a systematic review and timeline. Int J Obstet Anesth. Published 30 April 2024. doi:10.
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