Hydrocodone vs Oxycodone and Postoperative Pain and Opioid Use in Joint Arthroplasty
Authors' conclusion
In this cohort study of CYP2D6 NMs undergoing joint arthroplasty, within multimodal analgesia, hydrocodone provided comparable pain control to oxycodone with significantly lower opioid exposure
Study context
- Population
- CYP2D6 normal metabolizers undergoing elective joint arthroplasty, 5 US surgery sites, March 2021 to September 2023
- Participants
- 663 participants
- Comparison
- Hydrocodone vs Oxycodone
- Hydrocodonen = 446
- Oxycodonen = 217reference
- Primary endpoint
- Coprimary: composite pain score (sum of current, worst, and mean pain over 7 days; range 3-15) and cumulative MME over 10 days
- Follow-up
- Postoperative day 10
Methodological detailscohort study, preplanned secondary analysis, multicentre, multivariable-adjusted
- Cohort study
- Preplanned secondary analysis
- Multicentre
- Multivariable-adjusted
Secondary outcomes
Mean
| Outcome | Hydrocodone | Oxycodone | P value |
|---|---|---|---|
| Composite pain score (coprimary) · POD 10Adjusted P | 9.0 (SD 2.0) | 9.3 (SD 2.2) | P = 0.001 |
Original publication
Hydrocodone vs Oxycodone and Postoperative Pain and Opioid Use in Joint Arthroplasty. JAMA Netw Open. Published 1 July 2026. doi:10.
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