Pediatric anesthesia & critical care
Hydromorphone Versus Fentanyl‐Based Induction of Anesthesia for Postoperative Pain and Emergence Delirium in Children Undergoing Strabismus Surgery: A Randomized, Double‐Blind Comparative Study
Primary result · FLACC pain score at extubationResult — go to the resultMann-Whitney U 2457.0Authors' conclusion
Hydromorphone administration during induction may improve postoperative pain control and reduce the incidence of ED in PACU after pediatric strabismus surgery.
Study context
- Population
- Preschool children aged 3 to 7 years scheduled for strabismus surgery, West China Hospital153 received study drug
- Participants
- 186 children
- Comparison
- Hydromorphone vs Fentanyl
- Hydromorphonen = 77
- Fentanyln = 76reference
- Primary endpoint
- Face, Legs, Activity, Cry, and Consolability (FLACC) pain score
- Follow-up
- At extubation
Methodological detailsprospective, double-blind, Conducted at West China Hospital
- Prospective
- Double-blind
- Conducted at West China Hospital
Primary result
FLACC pain score at extubation
Mann-Whitney U
2457.0
P = 0.014
By group
Hydromorphone
0
median · IQR 0–0
Fentanyl
0
median · IQR 0–1
As reported in the abstract
Secondary outcomes
| Outcome | Hydromorphone | Fentanyl | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Emergence delirium | 75.3% | 93.4% | 0.8 (0.7–0.9) | P = 0.004 | |
| 0.512Relative risk (log scale) |
Rescue analgesia, Ramsay sedation scores, HR, MAP, SpO2 in PACU
- Comparable between the two groups
Safety
Perioperative adverse events
- Comparable between the two groups
Original publication
Hydromorphone Versus Fentanyl‐Based Induction of Anesthesia for Postoperative Pain and Emergence Delirium in Children Undergoing Strabismus Surgery: A Randomized, Double‐Blind Comparative Study. Paediatr Anaesth. Published 10 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →