Hyperfibrinolysis and reduced functional fibrinogen in haemorrhagic caesarean delivery: a secondary analysis of the TRACES trial evaluating fibrinogen kinetics following fibrinogen concentrate or plasma infusion
Authors' conclusion
Hyperfibrinolysis markedly impairs fibrinogen concentrate-mediated fibrinogen restoration during postpartum haemorrhage.
Study context
- Population
- Haemorrhagic caesarean delivery patients receiving fibrinogen concentrate during PPHof 151 trial patients
- Participants
- 34 patients
- Comparison
- Hyperfibrinolysis (HF) vs No HF among patients receiving fibrinogen concentrate
- HFn = 5
- Primary endpoint
- Fibrinogen restoration trajectories after first fibrinogen concentrate administration
Methodological detailsmulticentre, double-blind, placebo-controlled, exploratory
- Multicentre
- Double-blind
- Placebo-controlled
- Exploratory
Primary result
As reported in the abstract
Fibrinogen restoration
- HF vs No HF: P < 0.01
Further findings
Blood loss during PPH
- HF status associated with increased blood loss
Original publication
Hyperfibrinolysis and reduced functional fibrinogen in haemorrhagic caesarean delivery: a secondary analysis of the TRACES trial evaluating fibrinogen kinetics following fibrinogen concentrate or plasma infusion. Int J Obstet Anesth. Published 8 January 2026. doi:10.
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