Morbidity associated with fresh frozen plasma administration for postpartum hemorrhage requiring transfusion: a retrospective cohort study (2016–2024)
Authors' conclusion
Despite coagulopathy being uncommon during postpartum hemorrhage, fresh frozen plasma is often administered empirically in patients with normal INR and is associated with increased risk of adverse outcomes.
Study context
- Population
- Patients with PPH (quantitative blood loss ≥1000 mL) and international normliazed ratio (INR) ≤1.5 transfused any blood product during delivery admission, large tertiary academic center, 2016–2024INR ≤1.5 of 530 transfused
- Participants
- 489 patients
- Exposure
- FFP vs no FFP in transfused PPH with INR ≤1.5
- Outcome
- FFP use in transfused PPH with INR ≤1.5
Methodological detailssingle-centre, tertiary academic center
- Single-centre
- Tertiary academic center
Main finding
As reported in the abstract
Received FFP
37%
First FFP transfused before INR available
62.8%
Observational data: associations, not effects.
Further findings
- Higher adjusted odds of composite adverse outcomes, ICU admission and prolonged LOS with FFP
- Adjusted for significant covariates
Original publication
Morbidity associated with fresh frozen plasma administration for postpartum hemorrhage requiring transfusion: a retrospective cohort study (2016–2024). Int J Obstet Anesth. Published 8 March 2026. doi:10.
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