Cardiac arrest & resuscitation
Hyperoxemia after reperfusion in cardiac arrest patients: a potential dose–response association with 30-day survival
Authors' conclusion
In this nationwide observational study comprising both in- and out-of-hospital cardiac arrest patients, hyperoxemia at ICU admission was associated with lower 30-day survival.
Study context
- Population
- Adults with in- or out-of-hospital cardiac arrest admitted to an ICU requiring mechanical ventilation, Swedish registries, January 2010–March 20214,344 (44.6%) hyperoxemic
- Participants
- 9,735 adults
- Exposure
- PaO2 at ICU admission: mild, moderate, severe or extreme hyperoxemia, or hypoxemia vs normoxemia
- Normoxemian = 4,366reference
- Mildn = 2,217
- Moderaten = 1,091
- Severen = 507
- Extremen = 529
- Hypoxemian = 1,025
- Outcome
- 30-day survival
- Follow-up
- 30 days
Methodological detailsregistry-based, multivariable modified Poisson regression
- Registry-based
- Multivariable modified Poisson regression
Main finding
As reported in the abstract
Each group vs normoxemiaAdjusted RR for 30-day survival (95% CI)
Mild
0.91(0.85–0.97)
Moderate
0.88(0.82–0.95)
Severe
0.79(0.7–0.89)
Extreme
0.68(0.58–0.79)
Hypoxemia
0.83(0.74–0.92)
- Whole hyperoxemia group vs normoxemia, adjusted RR for 30-day survival
- 0.87 (95% CI 0.82-0.91)
Observational data: associations, not effects.
Further findings
30-day survival, OHCA and IHCA (subgroup)
- Similar associations in both OHCA and IHCA
Original publication
Hyperoxemia after reperfusion in cardiac arrest patients: a potential dose–response association with 30-day survival. Crit Care. Published 6 March 2023. doi:10.
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