Cardiac arrest & resuscitation
Inferior vena cava thrombosis associated with endovascular cooling catheters: impact on clinical outcomes
Authors' conclusion
Despite intravenous anticoagulation, IVC thrombosis remains a relevant complication of endovascular cooling. Though not associated with death or poor neurological outcomes, it was associated with high in-hospital bleeding rates and anticoagulant use at discharge.
Study context
- Population
- Comatose out-of-hospital cardiac arrest (OHCA) survivors treated with therapeutic hypothermia (mild 34 °C vs moderate 31 °C) using endovascular cooling catheters319 analysed
- Participants
- 367 survivors
- Comparison
- Inferior vena cava (IVC) thrombosis vs no IVC thrombosis
- IVC thrombosisn = 21
- Primary endpoint
- Death or poor neurological outcome
- Follow-up
- 180 days
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
P = 0.39
Further findings
Discharged on an anticoagulant
P < 0.0001
- IVC thrombosis incidence
- 6.6 % · 21
- IVC thrombosis incidence: of 319 after excluding 48 who died before ultrasonography
Safety
In-hospital bleeding · not statistically significant
P = 0.24
Original publication
Inferior vena cava thrombosis associated with endovascular cooling catheters: impact on clinical outcomes. Resuscitation. Published 20 August 2025. doi:10.
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