Cardiac arrest & resuscitation
Hyperoxia for accidental hypothermia and increased mortality: a post-hoc analysis of a multicenter prospective observational study
Primary result · 28-day mortalityResult — go to the resultOdds ratio 2.65 95% CI 1.47–4.78Authors' conclusion
Hyperoxia with PaO2 levels of 300 mmHg or higher before initiating rewarming was associated with increased 28-day mortality in patients with accidental hypothermia.
Study context
- Population
- Adults with accidental hypothermia (core temperature < 32 °C) without cardiac arrest, PaO2 measured in the ED, admitted 2019–2022eligible
- Participants
- 338 adults
- Comparison
- Hyperoxia vs no hyperoxia before rewarming
- Hyperoxian = 65
- Primary endpoint
- 28-day mortality
- Follow-up
- 28 days
Methodological detailspost-hoc analysis, nationwide multicentre, inverse probability weighting with propensity scores
- Post-hoc analysis
- Nationwide multicentre
- Inverse probability weighting with propensity scores
Primary result
As reported in the abstract
Odds ratio
2.65
95% CI 1.47–4.78
P < 0.001
Events by treatment group
Hyperoxia vs Without hyperoxia
OR 2.65 (95% CI 1.47–4.78); P < 0.001
- Inverse probability weighting (IPW) analyses with propensity scores: similar results, adjusted OR
- 1.65 (1.14-2.38); p = 0.008 (95% CI)
Further findings
28-day mortality by subgroup (age, cardiopulmonary disease, hemodynamic instability, hypothermia severity)
- Hyperoxia harmful in the elderly, those with cardiopulmonary diseases and severe hypothermia below 28 °C
- No effect on mortality in patients with hemodynamic instability on hospital arrival
Original publication
Hyperoxia for accidental hypothermia and increased mortality: a post-hoc analysis of a multicenter prospective observational study. Crit Care. Published 1 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →