Enteral citrulline supplementation versus placebo on Sequential Organ Failure Assessment (SOFA) score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial
Authors' conclusion
Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo.
Study context
- Population
- Critically ill adults under invasive mechanical ventilation without sepsis or septic shock, 4 intensive care unit (ICUs) in France, 2016–2019randomized
- Participants
- 120 participants
- Comparison
- Enteral L-citrulline vs placebo
- L-citrullinen = 60
- Placebon = 60reference
- Primary endpoint
- SOFA score
- Follow-up
- Day 7
Methodological detailsdouble-blind, multicentre
- Double-blind
- Multicentre
Primary result
As reported in the abstract
L-citrulline
4
IQR 2–6
Placebo
4
IQR 2–7
P = 0.9
Secondary outcomes
Plasma arginine · day 3
- Significantly increased in the treatment group
Immune parameters
- Remained unaffected
Original publication
Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial. Crit Care. Published 3 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →