Impact of Dexamethasone-Enriched Tumescent Anesthesia for Radiofrequency Ablation of Great Saphenous Vein (GSV) insufficiency: A Double-Blind Randomized Clinical Trial
Authors' conclusion
Dexamethasone enriched TLA fluid during RFA reduces early postoperative pain and ecchymosis without increasing complications.
Study context
- Population
- Adults with GSV insufficiency (CEAP C2-C5) undergoing radiofrequency ablationrandomized
- Participants
- 136 adults
- Comparison
- Treatment vs Control
- Treatmentn = 67
- Controln = 69reference
- Primary endpoint
- Post-operative pain (Visual Analogue Scale (VAS))
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Day 1
Treatment
1
median · IQR 0–2
Control
2
median · IQR 1–3
P = 0.010
Secondary outcomes
Median
| Outcome | Treatment | Control | P value |
|---|---|---|---|
| Post-operative pain (VAS) · Day 3 | 0 (IQR 0–1) | 1 (IQR 0–2) | P = 0.007 |
Venous Clinical Severity Score (VCSS), EQ-5D, GSV occlusion
- No significant differences
Safety
Ecchymosis
P = 0.042
Thrombosis
- No significant difference
Original publication
Impact of Dexamethasone-Enriched Tumescent Anesthesia for Radiofrequency Ablation of GSV insufficiency: A Double-Blind Randomized Clinical Trial. Ann Surg. Published 21 November 2025. doi:10.
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