Radiofrequency ablation versus intra-articular mesenchymal stem cell injection for knee osteoarthritis: a systematic review and network meta-analysis
Authors' conclusion
This analysis suggests that RFA and MSC are resilient treatment options in knee OA. Despite some study heterogeneity, these treatments consistently outperformed conventional treatments, particularly in the short to mid-term, although with varying levels of certainty in their efficacy.
Study context
- Population
- Patients with knee osteoarthritis
- Participants
- 2,371 patients · 34 randomized controlled trials (RCTs)
- Comparison
- Radiofrequency ablation (RFA) vs IA MSC vs conventional treatments
- Outcome
- Pain score and WOMAC
Methodological detailsfrequentist approach, SUCRA ranking
- Frequentist approach
- SUCRA ranking
Pooled result
As reported in the abstract
Pain and WOMAC · 3 and 6 months
- RFA and IA MSC significantly more effective than conventional treatments for pain at 3 and 6 months (moderate certainty)
- RFA had the highest SUCRA values for pain
- WOMAC: both RFA and MSC significantly improved at 3 months
- WOMAC at 6 months: RFA maintained its lead; MSC not significantly superior
- Moderate certainty
Original publication
Radiofrequency ablation versus intra-articular mesenchymal stem cell injection for knee osteoarthritis: a systematic review and network meta-analysis. Reg Anesth Pain Med. Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →