Cardiac arrest & resuscitation

The Impact of Hospital-Level Median Door-to-Extracorporeal Cardiopulmonary Resuscitation Time on the Prognosis of Patients With Refractory Out-of-Hospital Cardiac Arrest

Crit Care MedPublished Secondary analysis of the Japanese Association for Acute Medicine out-of-hospital cardiac arrest (OHCA) registry

Primary result · 30-day survivalResult — go to the resultOR for 30-day survival 1.36 95% CI 1.21–1.53

Authors' conclusion

Hospital-level median door-to-ECPR time is a crucial predictor of survival and neurologic outcomes in OHCA patients requiring ECPR.

Study context

Population
Adults with OHCA who underwent ECPR, 53 hospitals across Japan, 2014–2021
Participants
2,136 adults · 53 hospitals
Comparison
Hospitals with rapid vs delayed median door-to-ECPR time
Primary endpoint
30-day survival
Follow-up
30 days
Methodological detailsnationwide registry, propensity score weighting, multicentre
  • Nationwide registry
  • Propensity score weighting
  • Multicentre

Primary result

As reported in the abstract

OR for 30-day survival

1.36

95% CI 1.21–1.53

Rapid vs Delayed
OR for 30-day survival 1.36 (95% CI 1.21–1.53)

Secondary outcomes

OutcomeOR (95% CI)
Favorable neurologic outcome · 30 days1.47 (1.24–1.73)
Favorable neurologic outcome · 90 days1.47 (1.25–1.73)

Original publication

The Impact of Hospital-Level Median Door-to-Extracorporeal Cardiopulmonary Resuscitation Time on the Prognosis of Patients With Refractory Out-of-Hospital Cardiac Arrest. Crit Care Med. Published 16 July 2025. doi:10.1097/ccm.0000000000006808

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