Impact of a cumulative positive fluid balance during the first three ICU days in patients with sepsis: a propensity score-matched cohort study
Authors' conclusion
In patients with sepsis, a positive fluid balance on the first ICU day was not associated with mortality at day 28. In contrast, cumulative positive fluid balances on the second and third ICU days were associated with higher mortality at day 28.
Study context
- Population
- Patients with sepsis in the ICU, Korean Sepsis Alliance Database, 20 hospitalsincluded for matching · D1 483 · D2 373 · D3 392
- Participants
- 2,516 patients
- Exposure
- Positive fluid vs Negative fluid
- Outcome
- Mortality in the ICU
- Follow-up
- Day 28
Methodological detailsprospectively collected registry data, multicentre
- Prospectively collected registry data
- Multicentre
Main finding
As reported in the abstract
Mortality at day 28 by cohort
Positive fluid vs Negative fluidHazard ratio (95% CI)P value
D1 cohort (to first midnight), 483 matched pairs
1.17(0.85–1.60)
P = 0.354D2 cohort (to second midnight), 373 matched pairs
2.13(1.48–3.06)
P < 0.001D3 cohort (to third midnight), 392 matched pairs
1.56(1.10–2.22)
P = 0.012Observational data: associations, not effects.
Original publication
Impact of a cumulative positive fluid balance during the first three ICU days in patients with sepsis: a propensity score-matched cohort study. Ann Intensive Care. Published 19 October 2023. doi:10.
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