Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review
Authors' conclusion
Adverse childhood experience exposure is associated with poor analgesia-related outcomes
Study context
- Population
- Adults (≥18 yr) with any analgesia-related outcome
- Participants
- 137,395 adults · 66 studies
- Comparison
- ACE exposure vs no ACE exposure
- Outcome
- Analgesia-related outcomes:
- Use
- Benefits
- Harms of analgesic medications
Methodological detailsnarrative synthesis, Seven databases searched from inception to September 26, 2023, Outcome categories: use of analgesics (n=12), analgesic side-effects (n=4), substance misuse (n=45), lifetime drug overdose (n=2), endogenous pain signalling (n=4), other outcomes (n=2)
- Narrative synthesis
- Seven databases searched from inception to September 26, 2023
- Outcome categories: use of analgesics (n=12), analgesic side-effects (n=4), substance misuse (n=45), lifetime drug overdose (n=2), endogenous pain signalling (n=4), other outcomes (n=2)
Pooled result
As reported in the abstract
Analgesia-related outcomes
- ACE exposure associated with greater use of analgesic medication
- ACE exposure associated with greater risk and severity of substance misuse
- ACE exposure associated with greater risk of drug overdose
- ACE exposure associated with greater risk of attempted suicide in opioid dependency
- No studies assessed the effect of ACE exposure on potential benefits of analgesics
Safety
- ACE exposure associated with higher incidence of analgesic medication side-effects
Original publication
Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review. Br J Anaesth. Published 22 October 2024. doi:10.
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