Impact of aminoglycosides on survival rate and renal outcomes in patients with urosepsis: a multicenter retrospective study
Main findingResult — go to the resultAdjusted hazard ratio 0.65 CI 0.35–1.23Authors' conclusion
Including aminoglycosides in the empirical antibiotic therapy did not significantly improve 30-day survival in patients admitted to the ICU for urosepsis.
Study context
- Population
- Adults admitted to the intensive care unit (ICU) for urinary sepsis or septic shock, 4 ICUs of 3 university hospitals (APHP), January 2015–May 2022
- Participants
- 580 adults
- Exposure
- Empirical beta-lactam with vs without aminoglycosides
- Aminoglycosidesn = 444
- No aminoglycosidesn = 136reference
- Outcome
- Mortality
- Follow-up
- Day 30 after ICU admission
Methodological detailsmulticentre, propensity score weighting
- Multicentre
- Propensity score weighting
Main finding
As reported in the abstract
Adjusted hazard ratio
0.65
CI 0.35–1.23
P = 0.19
Events by group
Aminoglycosides vs No aminoglycosides
aHR 0.65 (CI 0.35–1.23); P = 0.19
Observational data: associations, not effects.
Secondary outcomes
Lack of renal recovery · day 30
- No significant difference, aminoglycosides vs no aminoglycosides
- aHR = 0.88 [0.49; 1.58], p = 0.67
- Propensity score weighting
Need for new renal replacement therapy (RRT) · within 30 days
- No significant difference, aminoglycosides vs no aminoglycosides
- aHR = 1.01 [0.54; 1.88], p = 0.97
- Propensity score weighting
Major Adverse Kidney Events at day 30 (MAKE 30)
- No significant difference, aminoglycosides vs no aminoglycosides
- aHR = 0.94 [0.60; 1.50], p = 0.81
- Propensity score weighting
ICU LOS among survivors
- No significant difference, aminoglycosides vs no aminoglycosides
- aHR = 1.07 [0.87; 1.31], p = 0.53
- Propensity score weighting
Original publication
Impact of aminoglycosides on survival rate and renal outcomes in patients with urosepsis: a multicenter retrospective study. Ann Intensive Care. Published 12 April 2025. doi:10.
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