Impact of different doses of remifentanil on postoperative pain and hyperalgesia: a prospective randomized controlled study and genotypic analysis
Authors' conclusion
While high doses of remifentanil significantly induced detectable hyperalgesia in a laboratory phenomenon, RIH had zero clinical impact on the patient's actual pain experience or analgesic requirements after surgery.
Study context
- Population
- Patients undergoing laparoscopic surgery
- Participants
- 268 patients
- Comparison
- High-dose vs low-dose vs no remifentanil
Methodological detailsprospective, genotypic analysis
- Prospective
- Genotypic analysis
Primary result
As reported in the abstract
Postoperative pain scores
- No differences in postoperative pain scores among the three groups
- P = 0.969
Further findings
Mechanical pain thresholds · postoperatively
- Significantly lower in Group H vs the other groups
- P < 0.001
SCN9A rs6746030 A allele and postoperative pain
- Associated with higher pain scores
- P = 0.002
- Associated with increased postoperative analgesic requirements
- P = 0.013
- Exploratory
Original publication
Impact of different doses of remifentanil on postoperative pain and hyperalgesia: a prospective randomized controlled study and genotypic analysis. J Clin Anesth. Published 30 March 2026. doi:10.
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