Opioid infusions at different times of the day produce varying degrees of opioid-induced hyperalgesia
Authors' conclusion
Opioid infusions administered at different times of day produced varying degrees of OIH, possibly related to circadian rhythms of metabolic enzyme activities.
Study context
- Population
- Rats (Sprague-Dawley, Wistar) and patients undergoing abdominal laparoscopic surgery under GA receiving remifentanil and sufentanil
- Participants
- 60 patients
- Comparison
- Opioid infusion at different times of day
- Outcome
- Postoperative opioid-induced hyperalgesia (OIH) in patients (pressure pain sensitivity at forearm, NRS), afternoon vs morning
Methodological detailsanimal experiments and clinical study
- Animal experiments and clinical study
Main finding
As reported in the abstract
- Afternoon group: higher pressure pain sensitivity at forearm and higher Numeric Rating Scale (NRS) than morning group
- Afternoon vs Morning: P = 0.002
- Afternoon vs Morning: P < 0.05
Original publication
Opioid infusions at different times of the day produce varying degrees of opioid-induced hyperalgesia. Br J Anaesth. Published 9 October 2023. doi:10.
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