Impact of Early Tracheostomy on Clinical Outcomes in Trauma Patients Admitted to the Intensive Care Unit: A Retrospective Causal Analysis
Authors' conclusion
The authors' study observed that ET was not associated with reduced mortality in trauma patients, but it was associated with reduced VAP risk and MV duration.
Study context
- Population
- Trauma patients with tracheostomy admitted to US ICUs (MIMIC-IV and eICU Collaborative Research Database)
- Participants
- 626 patients
- Exposure
- Early vs late tracheostomy from ICU admission
- Early tracheostomy (ET)n = 321
- Outcome
- Clinical outcomes:
- VAP
- MV duration
- Mortality
Methodological detailsmarginal structural Cox model with inverse probability weighting, time-dependent propensity-score matching, multicentre
- Marginal structural Cox model with inverse probability weighting
- Time-dependent propensity-score matching
- Multicentre
Main finding
As reported in the abstract
- ET associated with reduced ventilation-associated pneumonia (VAP) vs late tracheostomy (LT)
- ET associated with shorter mechanical ventilation (MV) duration vs LT
- No difference in mortality between the two groups
- Marginal structural Cox model (MSCM) and time-dependent propensity-score matching (PSM)
Observational data: associations, not effects.
Original publication
Impact of Early Tracheostomy on Clinical Outcomes in Trauma Patients Admitted to the Intensive Care Unit: A Retrospective Causal Analysis. J Cardiothorac Vasc Anesth. Published 25 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →