Pediatric anesthesia & critical care
Impact of Endogenous Melatonin Status on Perioperative Oxidative Stress in Pediatric Cardiac Surgery With Cardiopulmonary Bypass
Authors' conclusion
Oxidative DNA injury is strongly associated with postoperative myocardial stress in pediatric patients undergoing CPB. Prebypass melatonin status showed an exploratory, nonindependent relationship with perioperative oxidative stress, while oxidative stress markers were robustly linked to NT-proBNP.
Study context
- Population
- Children (neonates to 18 years) undergoing corrective cardiac surgery with cardiopulmonary bypass (CPB)
- Participants
- 80 children
- Outcome
- Prebypass melatonin vs postoperative urinary 8-OHdG
Methodological detailssingle-centre, tertiary care hospital
- Single-centre
- Tertiary care hospital
Main finding
As reported in the abstract
Higher prebypass melatonin tended to be associated with lower postoperative urinary 8-OHdG (r)
−0.300
p = 0.007
Observational data: associations, not effects.
Further findings
Postoperative 8-OHdG vs NT-proBNP · immediately and 24 hours after surgery
- Correlation immediately after surgery (r)
- 0.516 (p < 0.001)
- Correlation 24 h after surgery (r)
- 0.451 (p < 0.001)
- Multivariable analysis: 8-OHdG independent predictor of NT-proBNP; melatonin not
Postbypass melatonin vs age
- Positive correlation (r)
- 0.288 (p = 0.010)
Postbypass melatonin vs surgical duration
- Negative correlation (r)
- −0.230 (p = 0.040)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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