Neuroanesthesia & neurocritical care
Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis
Authors' conclusion
Fever was associated with poor neurological outcomes and mortality in patients with acute brain injury.
Study context
- Population
- Acute brain injury patients (non-anoxic) with body temperature/fever data during intensive care unit (ICU) admission
- Participants
- 460,825 patients · 180 studies
- Comparison
- Fever vs no fever
- Outcome
- Neurological outcome and mortality
- Follow-up
- At any time
Methodological detailsretrospective and prospective observational studies included
- Retrospective and prospective observational studies included
Pooled result
As reported in the abstract
Fever vs No feverPooled odds ratio (95% CI)
Unfavorable neurological outcome; I2:92%
2.37(2.08–2.71)
Death; I2:93%
1.31(1.28–1.34)
Further pooled results
| Outcome | Pooled OR (95% CI) | |
|---|---|---|
| Neurological deterioration | 1.10 (1.05–1.15) | |
| DCI (SAH) | 1.96 (1.73–2.22) | |
| Large infarct size | 2.94 (2.90–2.98) | |
| Hemorrhagic transformation (ischemic stroke) | 1.63 (1.34–1.97) | |
| Large hemorrhagic volume | 2.38 (1.94–2.93) | |
| 0.20.5125Pooled odds ratio (log scale) |
Original publication
Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis. Crit Care. Published 13 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →