Perioperative medicine & outcomes
Impact of frailty on in-hospital outcomes in nonagenarian ICU patients: a binational multicenter analysis of 8,220 cases
Main finding · Hospital mortalityResult — go to the resultAdjusted hazard ratio 1.352 95% CI 1.192–1.534Authors' conclusion
Frailty is a strong, independent predictor of hospital mortality and prolonged hospitalization in critically ill nonagenarians, even after adjusting for illness severity and comorbidities.
Study context
- Population
- Nonagenarians admitted to 211 intensive care units (ICUs) in Australia and New Zealand, 2017–2023, with documented Clinical Frailty Scale (CFS) scores (ANZICS Adult Patient Database)8,220 propensity matched
- Participants
- 16,439 participants
- Exposure
- Frail vs non-frail
- Outcome
- In-hospital mortality and LOS (ICU and hospital mortality, ICU and hospital LOS)
Methodological detailspropensity-score matched (1:1), multicentre registry, binational
- Propensity-score matched (1:1)
- Multicentre registry
- Binational
Main finding
Hospital mortality
Adjusted hazard ratio
1.352
95% CI 1.192–1.534
P < 0.001
Frail vs Non-frail
adjusted HR 1.352 (95% CI 1.192–1.534); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| ICU mortalityMatched cohort | adjusted HR 1.242 (95% CI 1.044–1.440) | P = 0.017 | |
| ICU mortality per one-point increase in CFS | OR 1.09 (95% CI 1.01–1.18) | P = 0.026 | |
| Hospital mortality per one-point increase in CFS | OR 1.19 (95% CI 1.10–1.28) | P < 0.001 | |
| 0.512Ratio (log scale) |
| Outcome | Adjusted β (95% CI) | P value |
|---|---|---|
| Hospital LOSProlonged hospital LOS | 1.051 (1.033–1.070) | P < 0.001 |
ICU lengths of stay (LOS)
- Frailty not associated with ICU LOS after adjustment
- P = 0.739
Original publication
Impact of frailty on in-hospital outcomes in nonagenarian ICU patients: a binational multicenter analysis of 8,220 cases. Crit Care. Published 27 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →