Perioperative medicine & outcomes
Impact of general vs. regional anaesthesia on one‐year clinical outcomes and healthcare utilisation after lower limb arthroplasty: a retrospective study
Main findingResult — go to the resultHazard ratio 1.12 95% CI 0.89–1.41Authors' conclusion
Although general anaesthesia and regional anaesthesia showed comparable one-year mortality, general anaesthesia was associated with lower risks of major depression and care provider dependency but higher readmission rates than regional anaesthesia.
Study context
- Population
- Patients aged 40–90 y undergoing hip or knee arthroplasty, 2010–202312,558 after matching
- Participants
- 247,142 patients
- Exposure
- GA vs RA for hip or knee arthroplasty
- Outcome
- All-cause mortality
- Follow-up
- one-year
Methodological detailspropensity-score matched, TriNetX Global Collaborative Network
- Propensity-score matched
- TriNetX Global Collaborative Network
Main finding
As reported in the abstract
Hazard ratio
1.12
95% CI 0.89–1.41
P = 0.322
GA vs RA
HR 1.12 (95% CI 0.89–1.41); P = 0.322
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Major depression · one-year | 0.82 (0.70–0.97) | P = 0.021 | |
| Care provider dependency · one-year | 0.47 (0.38–0.58) | P < 0.001 | |
| Readmission · one-year | 1.22 (1.16–1.29) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Subgroups by sex, age and timeframe (subgroup)
- Sex, age and evolving peri-operative care over time may influence the comparative outcomes of GA and RA
Original publication
Impact of general vs. regional anaesthesia on one‐year clinical outcomes and healthcare utilisation after lower limb arthroplasty: a retrospective study. Anaesthesia. Published 12 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →