Impact of increasing post-filter ionized calcium target on filter lifespan in renal replacement therapy with regional citrate anticoagulation: A before-and-after study
Main findingResult — go to the resultHazard ratio 1.020 CI 0.703–1.481Authors' conclusion
Increasing the post-filter iCa target level from 0.25-0.35 mmol/L to 0.30-0.40 mmol/L during RCA-CRRT does not reduce filter lifespan until clotting and may decrease unnecessary citrate exposure.
Study context
- Population
- Patients undergoing RCA-CRRT sessions without systemic anticoagulationContinuous renal replacement therapy (CRRT) sessions analysed
- Participants
- 1,037 patients
- Comparison
- Post-filter ionized calcium (iCa) target 0.30-0.40 vs 0.25-0.35 mmol/L during RCA-CRRT
- First periodn = 610reference
- Second periodn = 427
- Outcome
- Filter lifespan until clotting
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
1.020
CI 0.703–1.481
P = 0.92
Second period vs First period
HR 1.020 (CI 0.703–1.481); P = 0.92
Original publication
Impact of increasing post-filter ionized calcium target on filter lifespan in renal replacement therapy with regional citrate anticoagulation: A before-and-after study. J Crit Care. Published 26 June 2023. doi:10.
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